Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling.

Shimizu, Takeshi; Ueda, Jun; Ho, Jolene Caifeng; Iwasaki, Katsuhiko; Poellinger, Lorenz; Harada, Ichiro; Sawada, Yasuhiro

Shimizu, Takeshi; Ueda, Jun; Ho, Jolene Caifeng; Iwasaki, Katsuhiko; Poellinger, Lorenz; Harada, Ichiro; Sawada, Yasuhiro.

Affiliation

Shimizu T; Mechanobiology Institute, National University of Singapore, 5A Engineering Drive 1, Singapore.

Stem Cells ; 30(7): 1394-404, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22553165

Subject(s)

Cell Differentiation/physiology; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Glycogen Synthase Kinase 3/metabolism; src-Family Kinases/metabolism; Animals; Cell Differentiation/genetics; Enzyme Inhibitors; Glycogen Synthase Kinase 3/antagonists & inhibitors; Glycogen Synthase Kinase 3/genetics; Immunoblotting; Mice; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; RNA Interference; Shc Signaling Adaptor Proteins/genetics; Shc Signaling Adaptor Proteins/metabolism; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Src-Family Kinases / Glycogen Synthase Kinase 3 / Embryonic Stem Cells Limits: Animals Language: En Journal: Stem Cells Year: 2012 Document type: Article Affiliation country: Singapore Country of publication: United kingdom

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