Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

Negro, Roberto; Gobessi, Stefania; Longo, Pablo G; He, Yantao; Zhang, Zhong-Yin; Laurenti, Luca; Efremov, Dimitar G

Negro, Roberto; Gobessi, Stefania; Longo, Pablo G; He, Yantao; Zhang, Zhong-Yin; Laurenti, Luca; Efremov, Dimitar G.

Affiliation

Negro R; Molecular Hematology, International Centre for Genetic Engineering & Biotechnology, Campus A. Buzzati-Traverso, Rome, Italy.

Blood ; 119(26): 6278-87, 2012 Jun 28.

Article in En | MEDLINE | ID: mdl-22569400

Subject(s)

Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Oncogene Protein v-akt/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 22/physiology; Antigen Presentation/physiology; Autoantigens/immunology; Autoantigens/pharmacology; Autoimmunity/genetics; Cell Survival/genetics; Cells, Cultured; Enzyme Activation/genetics; Gene Knockdown Techniques; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/immunology; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism; Lymphocyte Activation/genetics; Lymphocyte Activation/physiology; Oncogene Protein v-akt/agonists; Protein Tyrosine Phosphatase, Non-Receptor Type 22/antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 22/metabolism; Substrate Specificity; Transfection; Up-Regulation/genetics; Up-Regulation/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Oncogene Protein v-akt / Protein Tyrosine Phosphatase, Non-Receptor Type 22 Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Blood Year: 2012 Document type: Article Affiliation country: Italy Country of publication: United States

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