Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.
J Microbiol Biotechnol
; 22(6): 814-7, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-22573159
ABSTRACT
In the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography, Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5- pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC50 value of 8.4 microgram/ml, without cytotoxicity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Agaricales
/
Biosynthetic Pathways
/
Furaldehyde
/
Melanins
/
Antimetabolites
Limits:
Animals
Language:
En
Journal:
J Microbiol Biotechnol
Year:
2012
Document type:
Article