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Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.
Grillo, Mark P; Tadano Lohr, Michelle; Wait, Jill C M.
Affiliation
  • Grillo MP; Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA. grillo@amgen.com
Drug Metab Dispos ; 40(8): 1515-26, 2012 Aug.
Article in En | MEDLINE | ID: mdl-22577085
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biotransformation / Mefenamic Acid / Glutathione Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biotransformation / Mefenamic Acid / Glutathione Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States