Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies.

Thakkar, Santosh V; Joshi, Sangeeta B; Jones, Matthew E; Sathish, Hasige A; Bishop, Steven M; Volkin, David B; Middaugh, C Russell

Thakkar, Santosh V; Joshi, Sangeeta B; Jones, Matthew E; Sathish, Hasige A; Bishop, Steven M; Volkin, David B; Middaugh, C Russell.

Affiliation

Thakkar SV; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047, USA.

J Pharm Sci ; 101(9): 3062-77, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22581714

Subject(s)

Antibodies, Monoclonal/chemistry; Arginine/chemistry; Excipients/chemistry; Immunoglobulin G/chemistry; Sucrose/chemistry; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Stability; Hydrogen-Ion Concentration; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Technology, Pharmaceutical/methods; Temperature; Ultrasonics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Sucrose / Immunoglobulin G / Excipients / Antibodies, Monoclonal Language: En Journal: J Pharm Sci Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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