Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials.

Fuchs, Tobias Christian; Frick, Katharina; Emde, Barbara; Czasch, Stephanie; von Landenberg, Friedrich; Hewitt, Philip

Fuchs, Tobias Christian; Frick, Katharina; Emde, Barbara; Czasch, Stephanie; von Landenberg, Friedrich; Hewitt, Philip.

Affiliation

Fuchs TC; Merck KGaA, Merck Serono, Toxicology, Darmstadt, Germany.

Toxicol Pathol ; 40(7): 1031-48, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22581810

Subject(s)

Biomarkers/urine; Drug Evaluation, Preclinical; Kidney Diseases/chemically induced; Toxicity Tests, Subacute/methods; Xenobiotics/toxicity; Acute Disease; Animals; Anti-Bacterial Agents/toxicity; Antimetabolites, Antineoplastic/toxicity; Cisplatin/toxicity; Dose-Response Relationship, Drug; Female; Kidney Diseases/pathology; Kidney Diseases/urine; Male; Puromycin/toxicity; Rats; Rats, Wistar; Vancomycin/toxicity

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Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Xenobiotics / Drug Evaluation, Preclinical / Toxicity Tests, Subacute / Kidney Diseases Type of study: Evaluation_studies / Prognostic_studies Limits: Animals Language: En Journal: Toxicol Pathol Year: 2012 Document type: Article Affiliation country: Germany

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