Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics.
Anticancer Agents Med Chem
; 13(1): 147-58, 2013 Jan.
Article
in En
| MEDLINE
| ID: mdl-22583426
ABSTRACT
Drugs that target microtubules are a successful class of anti-cancer agents that have been in clinical use for over two decades. Acquired resistance to these drugs, however, remains a serious problem. Microtubule alterations, such as tubulin mutations and altered ß- tubulin isotype expression, are prominent factors in development of resistance. Changes in actin and intermediate filament proteins can also mediate sensitivity to microtubule-targeting drugs. This review focuses on the mechanisms by which alterations in cytoskeletal proteins lead to drug resistance. This information will be helpful for improving the targeting of microtubule toxins.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tubulin
/
Cytoskeleton
/
Drug Resistance, Neoplasm
/
Tubulin Modulators
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Anticancer Agents Med Chem
Journal subject:
ANTINEOPLASICOS
/
QUIMICA
Year:
2013
Document type:
Article
Affiliation country:
New Zealand