A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.

Bertotti, Andrea; Migliardi, Giorgia; Galimi, Francesco; Sassi, Francesco; Torti, Davide; Isella, Claudio; Corà, Davide; Di Nicolantonio, Federica; Buscarino, Michela; Petti, Consalvo; Ribero, Dario; Russolillo, Nadia; Muratore, Andrea; Massucco, Paolo; Pisacane, Alberto; Molinaro, Luca; Valtorta, Emanuele; Sartore-Bianchi, Andrea; Risio, Mauro; Capussotti, Lorenzo; Gambacorta, Marcello; Siena, Salvatore; Medico, Enzo; Sapino, Anna; Marsoni, Silvia; Comoglio, Paolo M; Bardelli, Alberto; Trusolino, Livio

Bertotti, Andrea; Migliardi, Giorgia; Galimi, Francesco; Sassi, Francesco; Torti, Davide; Isella, Claudio; Corà, Davide; Di Nicolantonio, Federica; Buscarino, Michela; Petti, Consalvo; Ribero, Dario; Russolillo, Nadia; Muratore, Andrea; Massucco, Paolo; Pisacane, Alberto; Molinaro, Luca; Valtorta, Emanuele; Sartore-Bianchi, Andrea; Risio, Mauro; Capussotti, Lorenzo; Gambacorta, Marcello; Siena, Salvatore; Medico, Enzo; Sapino, Anna; Marsoni, Silvia; Comoglio, Paolo M; Bardelli, Alberto; Trusolino, Livio.

Affiliation

Bertotti A; Laboratory of Molecular Pharmacology, Division of Surgical Oncology, Unit of Pathology, Institute for Cancer Research and Treatment, Torino, Italy.

Cancer Discov ; 1(6): 508-23, 2011 Nov.

Article in En | MEDLINE | ID: mdl-22586653

Subject(s)

Antibodies, Monoclonal/pharmacology; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/enzymology; Receptor, ErbB-2/metabolism; Xenograft Model Antitumor Assays/methods; Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal, Humanized; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Cetuximab; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; Drug Resistance, Neoplasm; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/genetics; ErbB Receptors/metabolism; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Molecular Targeted Therapy; Prospective Studies; Receptor, ErbB-2/genetics; ras Proteins/genetics; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Receptor, ErbB-2 / Xenograft Model Antitumor Assays / Antibodies, Monoclonal Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Cancer Discov Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United States

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