Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.

Chen, Xuwang; Zhan, Peng; Liu, Xin; Cheng, Ziheng; Meng, Caicai; Shao, Siyuan; Pannecouque, Christophe; De Clercq, Erik; Liu, Xinyong

Chen, Xuwang; Zhan, Peng; Liu, Xin; Cheng, Ziheng; Meng, Caicai; Shao, Siyuan; Pannecouque, Christophe; De Clercq, Erik; Liu, Xinyong.

Affiliation

Chen X; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, 250012 Ji'nan, Shandong, PR China.

Bioorg Med Chem ; 20(12): 3856-64, 2012 Jun 15.

Article in En | MEDLINE | ID: mdl-22591854

Subject(s)

Anti-HIV Agents/pharmacology; Drug Design; HIV Reverse Transcriptase/antagonists & inhibitors; HIV-1/drug effects; HIV-2/drug effects; Reverse Transcriptase Inhibitors/chemical synthesis; Reverse Transcriptase Inhibitors/pharmacology; Amines/chemistry; Anti-HIV Agents/chemical synthesis; Anti-HIV Agents/chemistry; Cell Line, Tumor; Dose-Response Relationship, Drug; HIV Reverse Transcriptase/metabolism; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidines/chemistry; Reverse Transcriptase Inhibitors/chemistry; Structure-Activity Relationship; Triazines/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / HIV-1 / HIV-2 / Reverse Transcriptase Inhibitors / Anti-HIV Agents / HIV Reverse Transcriptase Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article

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