The role of small GTPases in neuronal morphogenesis and polarity.
Cytoskeleton (Hoboken)
; 69(7): 464-85, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22605667
ABSTRACT
The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Polarity
/
Monomeric GTP-Binding Proteins
/
Morphogenesis
/
Neurons
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cytoskeleton (Hoboken)
Year:
2012
Document type:
Article
Affiliation country:
Chile
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA