The role of small GTPases in neuronal morphogenesis and polarity.

Gonzalez-Billault, Christian; Muñoz-Llancao, Pablo; Henriquez, Daniel R; Wojnacki, José; Conde, Cecilia; Caceres, Alfredo

Gonzalez-Billault, Christian; Muñoz-Llancao, Pablo; Henriquez, Daniel R; Wojnacki, José; Conde, Cecilia; Caceres, Alfredo.

Affiliation

Gonzalez-Billault C; Faculty of Sciences, Laboratory of Cell and Neuronal Dynamics, Department of Biology and Institute for Cell Dynamics and Biotechnology, Universidad de Chile, Santiago, Chile. chrgonza@uchile.cl

Cytoskeleton (Hoboken) ; 69(7): 464-85, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22605667

ABSTRACT

ABSTRACT

The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation.

Subject(s)

Cell Polarity; Monomeric GTP-Binding Proteins/metabolism; Morphogenesis; Neurons/cytology; Neurons/enzymology; Animals; Humans; Models, Biological

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Polarity / Monomeric GTP-Binding Proteins / Morphogenesis / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cytoskeleton (Hoboken) Year: 2012 Document type: Article Affiliation country: Chile Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

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