[Misdiagnosed childhood sarcoidosis as non-Langerhans' cell histiocytosis treated with tumor necrosis factors-α antagonists]. / Sarcoidosis simulando una histiocitosis no Langerhans, tratada con antagonistas del factor de necrosis tumoral α
An Pediatr (Barc)
; 77(4): 267-71, 2012 Oct.
Article
in Es
| MEDLINE
| ID: mdl-22608978
ABSTRACT
Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin. Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans' cell histiocytosis (non-LCH). We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH. She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered. In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor-α antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoidosis
/
Histiocytosis, Non-Langerhans-Cell
/
Tumor Necrosis Factor-alpha
/
Diagnostic Errors
Type of study:
Diagnostic_studies
Limits:
Child
/
Female
/
Humans
Language:
Es
Journal:
An Pediatr (Barc)
Journal subject:
PEDIATRIA
Year:
2012
Document type:
Article