Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

Querbes, William; Bogorad, Roman L; Moslehi, Javid; Wong, Jamie; Chan, Amy Y; Bulgakova, Elena; Kuchimanchi, Satya; Akinc, Akin; Fitzgerald, Kevin; Koteliansky, Victor; Kaelin, William G

Querbes, William; Bogorad, Roman L; Moslehi, Javid; Wong, Jamie; Chan, Amy Y; Bulgakova, Elena; Kuchimanchi, Satya; Akinc, Akin; Fitzgerald, Kevin; Koteliansky, Victor; Kaelin, William G.

Affiliation

Querbes W; Alnylam Pharmaceuticals, Cambridge, MA 02215, USA. william_kaelin@dfci.harvard.edu

Blood ; 120(9): 1916-22, 2012 Aug 30.

Article in En | MEDLINE | ID: mdl-22611156

Subject(s)

Erythropoietin/deficiency; Erythropoietin/genetics; Procollagen-Proline Dioxygenase/genetics; RNA, Small Interfering/genetics; Anemia/etiology; Anemia/genetics; Anemia/therapy; Animals; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/metabolism; Base Sequence; Cells, Cultured; Erythropoiesis/genetics; Erythropoietin/metabolism; Feasibility Studies; Female; Hepcidins; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Inflammation/complications; Liver/enzymology; Liver/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Procollagen-Proline Dioxygenase/metabolism; RNA Interference; Renal Insufficiency/complications

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Erythropoietin / Procollagen-Proline Dioxygenase / RNA, Small Interfering Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Blood Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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