The number of p16INK4a positive cells in human skin reflects biological age.

Waaijer, Mariëtte E C; Parish, William E; Strongitharm, Barbara H; van Heemst, Diana; Slagboom, Pieternella E; de Craen, Anton J M; Sedivy, John M; Westendorp, Rudi G J; Gunn, David A; Maier, Andrea B

Waaijer, Mariëtte E C; Parish, William E; Strongitharm, Barbara H; van Heemst, Diana; Slagboom, Pieternella E; de Craen, Anton J M; Sedivy, John M; Westendorp, Rudi G J; Gunn, David A; Maier, Andrea B.

Affiliation

Waaijer ME; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Aging Cell ; 11(4): 722-5, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22612594

Subject(s)

Aging/metabolism; Aging/pathology; Cyclin-Dependent Kinase Inhibitor p16/metabolism; Skin/cytology; Skin/metabolism; Aged; Aged, 80 and over; Biomarkers/metabolism; Cell Count; Cellular Senescence/physiology; Epidermal Cells; Epidermis/metabolism; Female; Fibroblasts/cytology; Fibroblasts/metabolism; Humans; Longevity/physiology; Male; Middle Aged; Skin Aging/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Aging / Cyclin-Dependent Kinase Inhibitor p16 Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Aging Cell Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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