Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Horita, Yasuhiro; Takii, Takemasa; Yagi, Tetsuya; Ogawa, Kenji; Fujiwara, Nagatoshi; Inagaki, Emi; Kremer, Laurent; Sato, Yasuo; Kuroishi, Ryuji; Lee, Yoosa; Makino, Toshiaki; Mizukami, Hajime; Hasegawa, Tomohiro; Yamamoto, Ryuji; Onozaki, Kikuo

Horita, Yasuhiro; Takii, Takemasa; Yagi, Tetsuya; Ogawa, Kenji; Fujiwara, Nagatoshi; Inagaki, Emi; Kremer, Laurent; Sato, Yasuo; Kuroishi, Ryuji; Lee, Yoosa; Makino, Toshiaki; Mizukami, Hajime; Hasegawa, Tomohiro; Yamamoto, Ryuji; Onozaki, Kikuo.

Affiliation

Horita Y; Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.

Antimicrob Agents Chemother ; 56(8): 4140-5, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22615274

ABSTRACT

ABSTRACT

The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.

Subject(s)

Antitubercular Agents/pharmacology; Disulfiram/pharmacology; Ditiocarb/pharmacology; Extensively Drug-Resistant Tuberculosis/microbiology; Mycobacterium tuberculosis/drug effects; Tuberculosis, Multidrug-Resistant/microbiology; Tuberculosis/drug therapy; Animals; Antitubercular Agents/therapeutic use; Enzyme Inhibitors/pharmacology; Extensively Drug-Resistant Tuberculosis/drug therapy; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mycobacterium tuberculosis/isolation & purification; Tuberculosis/microbiology; Tuberculosis, Multidrug-Resistant/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / Tuberculosis, Multidrug-Resistant / Ditiocarb / Disulfiram / Extensively Drug-Resistant Tuberculosis / Mycobacterium tuberculosis / Antitubercular Agents Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2012 Document type: Article Affiliation country: Japan

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