The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus.

Nocjar, C; Zhang, J; Feng, P; Panksepp, J

Nocjar, C; Zhang, J; Feng, P; Panksepp, J.

Affiliation

Nocjar C; Department of Psychiatry, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. cxn18@cwru.edu

Neuroscience ; 218: 138-53, 2012 Aug 30.

Article in En | MEDLINE | ID: mdl-22626650

Subject(s)

Brain/metabolism; Depression/metabolism; Dynorphins/biosynthesis; Intracellular Signaling Peptides and Proteins/biosynthesis; Neuropeptides/biosynthesis; Prefrontal Cortex/metabolism; Ventral Tegmental Area/metabolism; Anhedonia; Animals; Disease Models, Animal; Dopamine/metabolism; Enzyme-Linked Immunosorbent Assay; Hypothalamus/metabolism; Male; Orexins; Radioimmunoassay; Rats; Rats, Long-Evans

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Brain / Dynorphins / Prefrontal Cortex / Ventral Tegmental Area / Intracellular Signaling Peptides and Proteins / Depression Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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