Monitoring for potential adverse effects of prenatal gene therapy: use of large animal models with relevance to human application.

Mehta, Vedanta; Abi-Nader, Khalil N; Carr, David; Wallace, Jacqueline; Coutelle, Charles; Waddington, Simon N; Peebles, Donald; David, Anna L

Mehta, Vedanta; Abi-Nader, Khalil N; Carr, David; Wallace, Jacqueline; Coutelle, Charles; Waddington, Simon N; Peebles, Donald; David, Anna L.

Affiliation

Mehta V; Prenatal Cell and Gene Therapy Group, EGA Institute for Women's Health, University College London, London, UK.

Methods Mol Biol ; 891: 291-328, 2012.

Article in En | MEDLINE | ID: mdl-22648778

Subject(s)

Fetal Monitoring; Genetic Therapy/adverse effects; Genetic Therapy/methods; Models, Animal; Prenatal Care/methods; Sheep/genetics; Animals; Biopsy; Blood Pressure/physiology; Blood Specimen Collection; Catheterization; Fetal Development; Fetus/anatomy & histology; Follow-Up Studies; Heart Rate/physiology; Humans; Immunity; Organ Specificity; Sheep/embryology; Sheep/immunology; Telemetry; Time Factors; Ultrasonography, Doppler; Ultrasonography, Prenatal; Uterine Artery/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prenatal Care / Sheep / Genetic Therapy / Models, Animal / Fetal Monitoring Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United States

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