Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins.

Miller, Nichol L G; Lawson, Christine; Chen, Xiao Lei; Lim, Ssang-Taek; Schlaepfer, David D

Miller, Nichol L G; Lawson, Christine; Chen, Xiao Lei; Lim, Ssang-Taek; Schlaepfer, David D.

Affiliation

Miller NL; Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America.

PLoS One ; 7(5): e37830, 2012.

Article in En | MEDLINE | ID: mdl-22649559

Subject(s)

Cell Movement/physiology; Focal Adhesions/metabolism; Guanine Nucleotide Exchange Factors/genetics; Wound Healing/physiology; ras-GRF1/genetics; rhoA GTP-Binding Protein/metabolism; Analysis of Variance; Animals; DNA Primers/genetics; Embryo, Mammalian/cytology; Fibroblasts/metabolism; Fibronectins/metabolism; Fluorescent Antibody Technique; Genotype; Guanine Nucleotide Exchange Factors/metabolism; Immunohistochemistry; Integrins/genetics; Integrins/metabolism; Mice; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; ras-GRF1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wound Healing / Cell Movement / RhoA GTP-Binding Protein / Guanine Nucleotide Exchange Factors / Ras-GRF1 / Focal Adhesions Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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