Suppression of premature termination codons as a therapeutic approach.

Keeling, Kim M; Wang, Dan; Conard, Sara E; Bedwell, David M

Keeling, Kim M; Wang, Dan; Conard, Sara E; Bedwell, David M.

Affiliation

Keeling KM; Department of Microbiology, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama, Birmingham, AL 35294-2170, USA.

Crit Rev Biochem Mol Biol ; 47(5): 444-63, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22672057

Subject(s)

Aminoglycosides/therapeutic use; Codon, Nonsense/metabolism; Genetic Diseases, Inborn/drug therapy; Peptide Chain Termination, Translational; Animals; Clinical Trials as Topic; Codon, Nonsense/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Genetic Diseases, Inborn/genetics; Genetic Diseases, Inborn/metabolism; Humans; Mice; Nonsense Mediated mRNA Decay; Phenotype; Protein Biosynthesis; Protein Synthesis Inhibitors/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Chain Termination, Translational / Codon, Nonsense / Aminoglycosides / Genetic Diseases, Inborn Limits: Animals / Humans Language: En Journal: Crit Rev Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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