Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.

Zhao, Min; Célérier, Isabelle; Bousquet, Elodie; Jeanny, Jean-Claude; Jonet, Laurent; Savoldelli, Michèle; Offret, Olivier; Curan, Antoine; Farman, Nicolette; Jaisser, Frédéric; Behar-Cohen, Francine

Zhao, Min; Célérier, Isabelle; Bousquet, Elodie; Jeanny, Jean-Claude; Jonet, Laurent; Savoldelli, Michèle; Offret, Olivier; Curan, Antoine; Farman, Nicolette; Jaisser, Frédéric; Behar-Cohen, Francine.

Affiliation

Zhao M; INSERM, U872, Team 17, Centre de Recherche des Cordeliers, Paris, France.

J Clin Invest ; 122(7): 2672-9, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22684104

Subject(s)

Central Serous Chorioretinopathy/metabolism; Mineralocorticoid Receptor Antagonists/therapeutic use; Receptors, Mineralocorticoid/metabolism; Spironolactone/analogs & derivatives; Vasodilator Agents/therapeutic use; Adult; Aldosterone/pharmacology; Aldosterone/physiology; Animals; Central Serous Chorioretinopathy/chemically induced; Central Serous Chorioretinopathy/drug therapy; Choroid/blood supply; Corticosterone; Eplerenone; Humans; Male; Middle Aged; Rats; Retina/pathology; Signal Transduction; Small-Conductance Calcium-Activated Potassium Channels/genetics; Small-Conductance Calcium-Activated Potassium Channels/metabolism; Spironolactone/therapeutic use; Treatment Outcome; Vasodilation/drug effects; Visual Acuity/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spironolactone / Vasodilator Agents / Receptors, Mineralocorticoid / Mineralocorticoid Receptor Antagonists / Central Serous Chorioretinopathy Type of study: Prognostic_studies Limits: Adult / Animals / Humans / Male / Middle aged Language: En Journal: J Clin Invest Year: 2012 Document type: Article Affiliation country: France

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