Cardiovascular properties of a nitric oxide releasing rofecoxib analogue: beneficial anti-hypertensive activity and enhanced recovery in an ischemic reperfusion injury model.

Bhardwaj, Atul; Batchu, Sri N; Kaur, Jatinder; Huang, Zhangjian; Seubert, John M; Knaus, Edward E

Bhardwaj, Atul; Batchu, Sri N; Kaur, Jatinder; Huang, Zhangjian; Seubert, John M; Knaus, Edward E.

Affiliation

Bhardwaj A; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6Gâ2N8, Canada.

ChemMedChem ; 7(8): 1365-8, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22689528

Subject(s)

Antihypertensive Agents/therapeutic use; Lactones/therapeutic use; Nitric Oxide/metabolism; Reperfusion Injury/drug therapy; Sulfones/therapeutic use; Animals; Antihypertensive Agents/chemistry; Antihypertensive Agents/pharmacology; Blood Pressure/drug effects; Cyclooxygenase 2/chemistry; Cyclooxygenase 2/metabolism; Disease Models, Animal; Drug Design; Female; Heart Rate/drug effects; Lactones/chemistry; Lactones/pharmacology; Mice; Mice, Inbred C57BL; Nitric Oxide Donors/chemistry; Nitric Oxide Donors/pharmacology; Nitric Oxide Donors/therapeutic use; Sulfones/chemistry; Sulfones/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Reperfusion Injury / Lactones / Antihypertensive Agents / Nitric Oxide Limits: Animals Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2012 Document type: Article Affiliation country: Canada Country of publication: Germany

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