The role of WDR5 in silencing human fetal globin gene expression.

Xu, Zhen; He, Yinghong; Ju, Junyi; Rank, Gerhard; Cerruti, Loretta; Ma, Chi; Simpson, Richard J; Moritz, Robert L; Jane, Stephen M; Zhao, Quan

Xu, Zhen; He, Yinghong; Ju, Junyi; Rank, Gerhard; Cerruti, Loretta; Ma, Chi; Simpson, Richard J; Moritz, Robert L; Jane, Stephen M; Zhao, Quan.

Affiliation

Xu Z; Molecular Immunology and Cancer Research Center, The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.

Haematologica ; 97(11): 1632-40, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22689669

Subject(s)

Erythroid Precursor Cells/metabolism; Fetal Globulins/biosynthesis; Gene Silencing/physiology; Histone-Lysine N-Methyltransferase/metabolism; Models, Biological; Promoter Regions, Genetic/physiology; Erythroid Precursor Cells/cytology; Female; Fetal Globulins/genetics; Gene Knockdown Techniques; Histone Deacetylase 1/genetics; Histone Deacetylase 1/metabolism; Histone-Lysine N-Methyltransferase/genetics; Histones/genetics; Histones/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Intracellular Signaling Peptides and Proteins; K562 Cells; Male; Methylation; Protein-Arginine N-Methyltransferases/genetics; Protein-Arginine N-Methyltransferases/metabolism; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Erythroid Precursor Cells / Histone-Lysine N-Methyltransferase / Promoter Regions, Genetic / Gene Silencing / Fetal Globulins / Models, Biological Limits: Female / Humans / Male Language: En Journal: Haematologica Year: 2012 Document type: Article Affiliation country: China Country of publication: Italy

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