Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice.
J Gen Virol
; 93(Pt 9): 2057-2061, 2012 Sep.
Article
in En
| MEDLINE
| ID: mdl-22694901
ABSTRACT
Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2(-/-)) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2(-/-) mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly, no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2(-/-) mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scrapie
/
Gene Deletion
/
Receptor, PAR-2
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
J Gen Virol
Year:
2012
Document type:
Article
Affiliation country:
Czech Republic