[Thrombophilic mutation by women with serious pregnancy complications]. / Výskyt trombofilních mutací zen se závaznými tehotenskými komplikacemi.
Ceska Gynekol
; 77(2): 171-4, 2012 Apr.
Article
in Cs
| MEDLINE
| ID: mdl-22702078
ABSTRACT
OBJECTIVE:
The purpose of this study was to determine whether maternal or fetal genotype frequencies of the inherited thrombophilic gene mutation (F V Leiden, F II) are altered in adverse pregnancy outcomes - severe preeclampsia, IUGR, abruption of placenta and stillbirth. DESIGN OF THE STUDY Retrospective study.SETTING:
Department of Gynecology and Obstetrics of the Teaching Hospital and the 2nd Medical Faculty of the Charles University in Prague.METHODS:
We studied 232 women who had pregnancy complications. All women were tested postpartum for mutation of factor V Leiden and G20210A prothrombine gene. At the same time were tested the newborns of those women.RESULTS:
In the group of women with preeklampsia (n=141) we have demonstrated 5 women with mutation encoding for F V, 5 women with mutation encoding for F II and 1 combination of both. In the group of IUGR 2 women with mutation F V, 1 with mutation F II a 1 combination of both were found. In women after stillbirth occure two mutation of F V, one mutation of F II and one combination of both. In the group with abruptio of placenta was 1 case of mutation F V and 3 cases of mutation F II. When we tested a newborn we found 4 cases of mutation F V and 3 cases of F II in the group with preeclampsia, 4 cases of mutation F V 3 cases od mutation of F II in the group with IUGR, no case in the group with abruptio of placenta and 1 case in a death fetus. There was no assotiation between any severe pregnancy complications and any of the maternal or fetal inherited thrombophilia.CONCLUSION:
Factor V Leiden and prothrombin gene mutations did not seem play a significant role in adverse pregnancy outcome in our population.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Factor V
/
Prothrombin
/
Abruptio Placentae
/
Stillbirth
/
Mutation
Type of study:
Observational_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
Cs
Journal:
Ceska Gynekol
Journal subject:
GINECOLOGIA
Year:
2012
Document type:
Article
Publication country:
CZ
/
CZECH REPUBLIC
/
REPUBLICA CHECA
/
REPÚBLICA TCHECA