Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity.

Li, Xi; Liu, Jia-Lin; Yang, Xian-Hui; Lu, Xiang; Zhao, Ting-Ting; Gong, Hai-Bin; Zhu, Hai-Liang

Li, Xi; Liu, Jia-Lin; Yang, Xian-Hui; Lu, Xiang; Zhao, Ting-Ting; Gong, Hai-Bin; Zhu, Hai-Liang.

Affiliation

Li X; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

Bioorg Med Chem ; 20(14): 4430-6, 2012 Jul 15.

Article in En | MEDLINE | ID: mdl-22705022

Subject(s)

Acrylamides/chemistry; Antineoplastic Agents/chemical synthesis; Histone Deacetylase Inhibitors/chemical synthesis; Histone Deacetylases/chemistry; Pyrazoles/chemistry; Acrylamides/chemical synthesis; Acrylamides/toxicity; Antineoplastic Agents/chemistry; Antineoplastic Agents/toxicity; Binding Sites; Cell Line, Tumor; Cell Proliferation/drug effects; Computer Simulation; Drug Screening Assays, Antitumor; HCT116 Cells; Histone Deacetylase Inhibitors/chemistry; Histone Deacetylase Inhibitors/toxicity; Histone Deacetylases/metabolism; Humans; Protein Structure, Tertiary; Pyrazoles/chemical synthesis; Pyrazoles/toxicity; Structure-Activity Relationship

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Acrylamides / Histone Deacetylase Inhibitors / Histone Deacetylases / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google