Non-canonical signaling of the PTH receptor.
Trends Pharmacol Sci
; 33(8): 423-31, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22709554
ABSTRACT
The classical model of arrestin-mediated desensitization of cell-surface G-protein-coupled receptors (GPCRs) is thought to be universal. However, this paradigm is incompatible with recent reports that the parathyroid hormone (PTH) receptor (PTHR), a crucial GPCR for bone and mineral ion metabolism, sustains G(S) activity and continues to generate cAMP for prolonged periods after ligand washout; during these periods the receptor is observed mainly in endosomes, associated with the bound ligand, G(S) and ß-arrestins. In this review we discuss possible molecular mechanisms underlying sustained signaling by the PTHR, including modes of signal generation and attenuation within endosomes, as well as the biological relevance of such non-canonical signaling.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Receptors, Parathyroid Hormone
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Pharmacol Sci
Year:
2012
Document type:
Article
Affiliation country:
United States