Low-dose thromboxane A2 receptor stimulation promotes closure of the rat ductus arteriosus with minimal adverse effects.

Yokota, Tomohiro; Aida, Takashi; Ichikawa, Yasuhiro; Fujita, Takayuki; Yokoyama, Utako; Minamisawa, Susumu

Yokota, Tomohiro; Aida, Takashi; Ichikawa, Yasuhiro; Fujita, Takayuki; Yokoyama, Utako; Minamisawa, Susumu.

Affiliation

Yokota T; Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, Tokyo, Japan.

Pediatr Res ; 72(2): 129-36, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22717688

Subject(s)

Ductus Arteriosus, Patent/prevention & control; Ductus Arteriosus/growth & development; Receptors, Thromboxane A2, Prostaglandin H2/agonists; Vasoconstriction/drug effects; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology; Analysis of Variance; Animals; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Capillaries/pathology; Cryopreservation; Dose-Response Relationship, Drug; Ductus Arteriosus/drug effects; Fatty Acids, Unsaturated/pharmacology; Fetus; Pulmonary Alveoli/blood supply; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction

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Collection: 01-internacional Database: MEDLINE Main subject: Vasoconstriction / Receptors, Thromboxane A2, Prostaglandin H2 / Ductus Arteriosus / Ductus Arteriosus, Patent Limits: Animals Language: En Journal: Pediatr Res Year: 2012 Document type: Article Affiliation country: Japan

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