Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of ß-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.

Yang, Yu-Shun; Zhang, Fei; Gao, Chao; Zhang, Yan-Bin; Wang, Xiao-Liang; Tang, Jian-Feng; Sun, Jian; Gong, Hai-Bin; Zhu, Hai-Liang

Yang, Yu-Shun; Zhang, Fei; Gao, Chao; Zhang, Yan-Bin; Wang, Xiao-Liang; Tang, Jian-Feng; Sun, Jian; Gong, Hai-Bin; Zhu, Hai-Liang.

Affiliation

Yang YS; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

Bioorg Med Chem Lett ; 22(14): 4619-24, 2012 Jul 15.

Article in En | MEDLINE | ID: mdl-22721711

Subject(s)

3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/antagonists & inhibitors; Enzyme Inhibitors/chemistry; Heterocyclic Compounds/chemistry; Pyrazoles/chemistry; Sulfur Compounds/chemistry; Drug Discovery; Enzyme Inhibitors/pharmacology; Heterocyclic Compounds/pharmacology; Hydrogen Bonding; Microbial Viability/drug effects; Models, Molecular; Molecular Structure; Pyrazoles/pharmacology; Structure-Activity Relationship; Sulfur Compounds/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Pyrazoles / Sulfur Compounds / Enzyme Inhibitors / Heterocyclic Compounds Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article

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