Embryonic stem cell potency fluctuates with endogenous retrovirus activity.

Macfarlan, Todd S; Gifford, Wesley D; Driscoll, Shawn; Lettieri, Karen; Rowe, Helen M; Bonanomi, Dario; Firth, Amy; Singer, Oded; Trono, Didier; Pfaff, Samuel L

Macfarlan, Todd S; Gifford, Wesley D; Driscoll, Shawn; Lettieri, Karen; Rowe, Helen M; Bonanomi, Dario; Firth, Amy; Singer, Oded; Trono, Didier; Pfaff, Samuel L.

Affiliation

Macfarlan TS; Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, California 92037, USA.

Nature ; 487(7405): 57-63, 2012 Jul 05.

Article in En | MEDLINE | ID: mdl-22722858

Subject(s)

Cell Dedifferentiation/genetics; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Endogenous Retroviruses/genetics; Pluripotent Stem Cells/cytology; Totipotent Stem Cells/cytology; Totipotent Stem Cells/metabolism; Animals; Cell Dedifferentiation/physiology; Cell Lineage/genetics; Chimera/embryology; Chromatin/genetics; Chromatin/metabolism; Embryo, Mammalian/cytology; Embryo, Mammalian/metabolism; Embryo, Mammalian/virology; Embryonic Stem Cells/virology; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Reporter/genetics; Histones/chemistry; Histones/metabolism; Induced Pluripotent Stem Cells/cytology; Induced Pluripotent Stem Cells/metabolism; Lysine/chemistry; Lysine/metabolism; Methylation; Mice; Phenotype; Pluripotent Stem Cells/metabolism; Pluripotent Stem Cells/virology; Terminal Repeat Sequences/genetics; Totipotent Stem Cells/virology; Transcriptome/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endogenous Retroviruses / Pluripotent Stem Cells / Totipotent Stem Cells / Embryonic Stem Cells / Cell Dedifferentiation Limits: Animals Language: En Journal: Nature Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google