Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags.

Kumru, Ozan S; Liu, Jun; Ji, Junyan A; Cheng, Wilson; Wang, Y John; Wang, Tingting; Joshi, Sangeeta B; Middaugh, C Russell; Volkin, David B

Kumru, Ozan S; Liu, Jun; Ji, Junyan A; Cheng, Wilson; Wang, Y John; Wang, Tingting; Joshi, Sangeeta B; Middaugh, C Russell; Volkin, David B.

Affiliation

Kumru OS; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047, USA.

J Pharm Sci ; 101(10): 3636-50, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22733600

Subject(s)

Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/immunology; Immunoglobulin G/immunology; Administration, Intravenous/methods; Antibodies, Monoclonal/administration & dosage; Chemistry, Pharmaceutical/methods; Drug Stability; Drug Storage; Humans; Immunoglobulin G/administration & dosage; Immunoglobulin G/chemistry; Infusions, Intravenous/methods; Nephelometry and Turbidimetry; Particle Size; Protein Structure, Tertiary; Proteins/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Antibodies, Monoclonal Limits: Humans Language: En Journal: J Pharm Sci Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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