HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-&#954;B and depends on chronically activated IKK&#945; and p65/RelA.

Ho, Yik-Khuan; Zhi, Huijun; DeBiaso, Dominic; Philip, Subha; Shih, Hsiu-Ming; Giam, Chou-Zen

HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.

Ho, Yik-Khuan; Zhi, Huijun; DeBiaso, Dominic; Philip, Subha; Shih, Hsiu-Ming; Giam, Chou-Zen.

Affiliation

Ho YK; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

J Virol ; 86(17): 9474-83, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22740410

Subject(s)

Cellular Senescence; Gene Products, tax/metabolism; HTLV-I Infections/physiopathology; Human T-lymphotropic virus 1/metabolism; I-kappa B Kinase/genetics; NF-kappa B/metabolism; Transcription Factor RelA/genetics; Transcriptional Activation; Cell Line; Enzyme Activation; Gene Expression Regulation; Gene Products, tax/genetics; HTLV-I Infections/genetics; HTLV-I Infections/metabolism; HTLV-I Infections/virology; Human T-lymphotropic virus 1/genetics; Humans; I-kappa B Kinase/metabolism; NF-kappa B/genetics; Transcription Factor RelA/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Human T-lymphotropic virus 1 / HTLV-I Infections / Transcriptional Activation / Gene Products, tax / NF-kappa B / Cellular Senescence / I-kappa B Kinase / Transcription Factor RelA Limits: Humans Language: En Journal: J Virol Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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