Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues.
Eur J Med Chem
; 54: 931-5, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22770606
ABSTRACT
Stearic acid, a saturated fatty acid was isolated from the microalga Spirulina platensis. Some novel stearic acid analogues having 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole are synthesized and characterized by IR, NMR and mass spectral analysis. All the synthesized compounds were screened for antimicrobial activity by using cup plate method. The synthesized compounds have been further screened for their antidepressant activity in swiss albino mice by forced swim test (FST), midbrain dopamine has been estimated and quantified. All the compounds showed good antimicrobial activity and compound 6 showed significant antidepressant activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stearic Acids
/
Anti-Infective Agents
/
Antidepressive Agents
Limits:
Animals
Language:
En
Journal:
Eur J Med Chem
Year:
2012
Document type:
Article
Affiliation country:
India