Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.

Khomane, Kailas S; Nandekar, Prajwal P; Wahlang, Banrida; Bagul, Pravin; Shaikh, Naeem; Pawar, Yogesh B; Meena, Chhuttan Lal; Sangamwar, Abhay T; Jain, Rahul; Tikoo, K; Bansal, Arvind K

Khomane, Kailas S; Nandekar, Prajwal P; Wahlang, Banrida; Bagul, Pravin; Shaikh, Naeem; Pawar, Yogesh B; Meena, Chhuttan Lal; Sangamwar, Abhay T; Jain, Rahul; Tikoo, K; Bansal, Arvind K.

Affiliation

Khomane KS; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector-67, SAS Nagar, Mohali, Punjab, India.

Mol Pharm ; 9(9): 2458-68, 2012 Sep 04.

Article in En | MEDLINE | ID: mdl-22779445

Subject(s)

Anticonvulsants/pharmacokinetics; Symporters/metabolism; Thyrotropin-Releasing Hormone/analogs & derivatives; Amoxicillin/pharmacology; Anticonvulsants/chemistry; Anticonvulsants/metabolism; Biological Transport/drug effects; Caco-2 Cells; Cell Line, Tumor; Dipeptides/pharmacology; Drug Stability; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption/drug effects; Intestinal Mucosa/metabolism; Intestines/drug effects; Models, Molecular; Molecular Dynamics Simulation; Peptide Transporter 1; Sodium/metabolism; Sodium Azide/metabolism; Symporters/chemistry; Thyrotropin-Releasing Hormone/chemistry; Thyrotropin-Releasing Hormone/metabolism; Thyrotropin-Releasing Hormone/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyrotropin-Releasing Hormone / Symporters / Anticonvulsants Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: India Country of publication: United States

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