Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells.

Bolzoni, M; Donofrio, G; Storti, P; Guasco, D; Toscani, D; Lazzaretti, M; Bonomini, S; Agnelli, L; Capocefalo, A; Dalla Palma, B; Neri, A; Nicolini, F; Lisignoli, G; Russo, F; Colla, S; Aversa, F; Giuliani, N

Bolzoni, M; Donofrio, G; Storti, P; Guasco, D; Toscani, D; Lazzaretti, M; Bonomini, S; Agnelli, L; Capocefalo, A; Dalla Palma, B; Neri, A; Nicolini, F; Lisignoli, G; Russo, F; Colla, S; Aversa, F; Giuliani, N.

Affiliation

Bolzoni M; Hematology and BMT Center, University of Parma, Parma, Italy.

Leukemia ; 27(2): 451-63, 2013 Feb.

Article in En | MEDLINE | ID: mdl-22781592

Subject(s)

Bone Marrow Cells/cytology; Cell Differentiation; Multiple Myeloma/pathology; Osteoblasts/cytology; Osteogenesis; Proto-Oncogene Proteins/metabolism; Receptor Tyrosine Kinase-like Orphan Receptors/metabolism; Stem Cells/cytology; Wnt Proteins/metabolism; Animals; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Blotting, Western; Bone Marrow Cells/metabolism; Case-Control Studies; Cell Proliferation; Coculture Techniques; Flow Cytometry; Gene Expression Profiling; Humans; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/metabolism; Mice; Multiple Myeloma/genetics; Multiple Myeloma/metabolism; Oligonucleotide Array Sequence Analysis; Osteoblasts/metabolism; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/genetics; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Receptor Tyrosine Kinase-like Orphan Receptors/genetics; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stem Cells/metabolism; Wnt Proteins/antagonists & inhibitors; Wnt Proteins/genetics; Wnt-5a Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Osteogenesis / Stem Cells / Bone Marrow Cells / Cell Differentiation / Proto-Oncogene Proteins / Wnt Proteins / Receptor Tyrosine Kinase-like Orphan Receptors / Multiple Myeloma Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2013 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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