Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury.

Sharma, Amy M; Li, Yan; Novalen, Maria; Hayes, M Anthony; Uetrecht, Jack

Sharma, Amy M; Li, Yan; Novalen, Maria; Hayes, M Anthony; Uetrecht, Jack.

Affiliation

Sharma AM; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 3M2.

Chem Res Toxicol ; 25(8): 1708-19, 2012 Aug 20.

Article in En | MEDLINE | ID: mdl-22793666

Subject(s)

Chemical and Drug Induced Liver Injury/metabolism; Indolequinones/toxicity; Nevirapine/toxicity; Animals; Antibodies/immunology; Aryl Hydrocarbon Hydroxylases/chemistry; Aryl Hydrocarbon Hydroxylases/metabolism; Chemical and Drug Induced Liver Injury/pathology; Cytochrome P-450 CYP3A/chemistry; Cytochrome P-450 CYP3A/metabolism; Cytochrome P450 Family 2; Female; Humans; Indolequinones/chemistry; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Nevirapine/chemistry; Nevirapine/metabolism; Oxidation-Reduction; Rats; Rats, Inbred BN; Steroid 16-alpha-Hydroxylase/chemistry; Steroid 16-alpha-Hydroxylase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nevirapine / Indolequinones / Chemical and Drug Induced Liver Injury Limits: Animals / Female / Humans / Male Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2012 Document type: Article

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