Targeting BRAFV600E in an inducible murine model of melanoma.

Hooijkaas, Anna I; Gadiot, Jules; van der Valk, Martin; Mooi, Wolter J; Blank, Christian U

Hooijkaas, Anna I; Gadiot, Jules; van der Valk, Martin; Mooi, Wolter J; Blank, Christian U.

Affiliation

Hooijkaas AI; Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Am J Pathol ; 181(3): 785-94, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22796458

Subject(s)

Amino Acid Substitution/genetics; Melanoma/pathology; Molecular Targeted Therapy; Proto-Oncogene Proteins B-raf/genetics; Skin Neoplasms/pathology; Animals; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Cell Transformation, Neoplastic/pathology; Disease Models, Animal; Drug Administration Routes; Humans; Indoles/administration & dosage; Indoles/blood; Integrases/metabolism; Lymphatic Metastasis/pathology; Lymphocytes, Tumor-Infiltrating/immunology; Lymphocytes, Tumor-Infiltrating/pathology; Melanoma/blood; Melanoma/immunology; Mice; Mice, Inbred C57BL; Mutation/genetics; PTEN Phosphohydrolase/genetics; Skin Neoplasms/blood; Skin Neoplasms/immunology; Sulfonamides/administration & dosage; Sulfonamides/blood; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Amino Acid Substitution / Proto-Oncogene Proteins B-raf / Molecular Targeted Therapy / Melanoma Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: United States

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