Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-ß3-pseudopeptide agonist.

Neveu, Cindy; Lefranc, Benjamin; Tasseau, Olivier; Do-Rego, Jean-Claude; Bourmaud, Adèle; Chan, Philippe; Bauchat, Patrick; Le Marec, Olivier; Chuquet, Julien; Guilhaudis, Laure; Boutin, Jean A; Ségalas-Milazzo, Isabelle; Costentin, Jean; Vaudry, Hubert; Baudy-Floc'h, Michèle; Vaudry, David; Leprince, Jérôme

Neveu, Cindy; Lefranc, Benjamin; Tasseau, Olivier; Do-Rego, Jean-Claude; Bourmaud, Adèle; Chan, Philippe; Bauchat, Patrick; Le Marec, Olivier; Chuquet, Julien; Guilhaudis, Laure; Boutin, Jean A; Ségalas-Milazzo, Isabelle; Costentin, Jean; Vaudry, Hubert; Baudy-Floc'h, Michèle; Vaudry, David; Leprince, Jérôme.

Affiliation

Neveu C; Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine (IRIB), INSERM U982, 76821 Mont-Saint-Aignan, France.

J Med Chem ; 55(17): 7516-24, 2012 Sep 13.

Article in En | MEDLINE | ID: mdl-22800498

Subject(s)

Aza Compounds/pharmacology; Drug Design; Feeding Behavior/drug effects; Peptides/pharmacology; Receptors, G-Protein-Coupled/agonists; Animals; Circular Dichroism; Drug Stability; Hydrogen Bonding; Injections, Intraventricular; Male; Mice; Molecular Weight; Peptides/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Aza Compounds / Drug Design / Receptors, G-Protein-Coupled / Feeding Behavior Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: France

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