Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology.

Zaidi, Tanweer S; Zaidi, Tauqeer; Pier, Gerald B; Priebe, Gregory P

Zaidi, Tanweer S; Zaidi, Tauqeer; Pier, Gerald B; Priebe, Gregory P.

Affiliation

Zaidi TS; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Infect Immun ; 80(10): 3706-12, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22802348

Subject(s)

Antibodies, Neutralizing/immunology; Corneal Ulcer/microbiology; Corneal Ulcer/pathology; Interleukin-17/metabolism; Pseudomonas Infections/immunology; Pseudomonas aeruginosa/physiology; Animals; Corneal Ulcer/prevention & control; Disease Models, Animal; Gene Expression Regulation/immunology; Intercellular Adhesion Molecule-1/genetics; Intercellular Adhesion Molecule-1/metabolism; Interleukin-17/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interleukin-17/genetics; Receptors, Interleukin-17/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pseudomonas Infections / Corneal Ulcer / Interleukin-17 / Antibodies, Neutralizing Type of study: Prognostic_studies Limits: Animals Language: En Journal: Infect Immun Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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