Relating particle formation to salt- and pH-dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A.

Kroetsch, Andrew M; Sahin, Erinc; Wang, Hsiang-yun; Krizman, Sintia; Roberts, Christopher J

Kroetsch, Andrew M; Sahin, Erinc; Wang, Hsiang-yun; Krizman, Sintia; Roberts, Christopher J.

Affiliation

Kroetsch AM; Department of Chemical and Biomolecular Engineering, and Center for Molecular Thermodynamics, University of Delaware, Newark, Delaware 19716, USA.

J Pharm Sci ; 101(10): 3651-60, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22806414

Subject(s)

Chymotrypsinogen/chemistry; Sodium Chloride/chemistry; Anions/chemistry; Drug Storage; Hydrogen-Ion Concentration; Kinetics; Phase Transition; Protein Binding; Solutions/chemistry; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium Chloride / Chymotrypsinogen Language: En Journal: J Pharm Sci Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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