Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.

Cremasco, Viviana; Decker, Corinne E; Stumpo, Deborah; Blackshear, Perry J; Nakayama, Keiichi I; Nakayama, Keiko; Lupu, Traian S; Graham, Daniel B; Novack, Deborah V; Faccio, Roberta

Cremasco, Viviana; Decker, Corinne E; Stumpo, Deborah; Blackshear, Perry J; Nakayama, Keiichi I; Nakayama, Keiko; Lupu, Traian S; Graham, Daniel B; Novack, Deborah V; Faccio, Roberta.

Affiliation

Cremasco V; Department of Orthopaedics, Washington University School of Medicine, St. Louis, MO, USA.

J Bone Miner Res ; 27(12): 2452-63, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22806935

Subject(s)

Bone Resorption/physiopathology; Cathepsin K/metabolism; Lysosomes/metabolism; Osteoclasts/physiology; Protein Kinase C-delta/deficiency; Animals; Bone and Bones/metabolism; Cell Membrane/metabolism; Exocytosis/physiology; Homeostasis/drug effects; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Lysosomes/enzymology; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Osteoclasts/metabolism; Vacuolar Proton-Translocating ATPases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Bone Resorption / Protein Kinase C-delta / Cathepsin K / Lysosomes Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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