GSK3ß inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation.

John, Jobin K; Paraiso, Kim H T; Rebecca, Vito W; Cantini, Liliana P; Abel, Ethan V; Pagano, Nicholas; Meggers, Eric; Mathew, Rahel; Krepler, Clemens; Izumi, Victoria; Fang, Bin; Koomen, John M; Messina, Jane L; Herlyn, Meenhard; Smalley, Keiran S M

John, Jobin K; Paraiso, Kim H T; Rebecca, Vito W; Cantini, Liliana P; Abel, Ethan V; Pagano, Nicholas; Meggers, Eric; Mathew, Rahel; Krepler, Clemens; Izumi, Victoria; Fang, Bin; Koomen, John M; Messina, Jane L; Herlyn, Meenhard; Smalley, Keiran S M.

Affiliation

John JK; Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

J Invest Dermatol ; 132(12): 2818-27, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22810307

Subject(s)

Antigens, CD/genetics; Cadherins/genetics; Focal Adhesion Kinase 1/metabolism; Glycogen Synthase Kinase 3/metabolism; Melanoma/enzymology; Skin Neoplasms/enzymology; Antigens, CD/metabolism; Cadherins/metabolism; Cell Line, Tumor; Cell Movement/drug effects; Cell Movement/physiology; Down-Regulation/drug effects; Down-Regulation/genetics; Endothelial Cells/cytology; Endothelial Cells/enzymology; Enzyme Inhibitors/pharmacology; Fibroblasts/cytology; Fibroblasts/enzymology; Focal Adhesions/drug effects; Focal Adhesions/physiology; Glycogen Synthase Kinase 3/antagonists & inhibitors; Glycogen Synthase Kinase 3/genetics; Glycogen Synthase Kinase 3 beta; Humans; Melanoma/pathology; Neoplasm Invasiveness; Phosphorylation/drug effects; Phosphorylation/physiology; RNA, Small Interfering/genetics; Signal Transduction/drug effects; Signal Transduction/physiology; Skin Neoplasms/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Antigens, CD / Cadherins / Glycogen Synthase Kinase 3 / Focal Adhesion Kinase 1 / Melanoma Limits: Humans Language: En Journal: J Invest Dermatol Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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