Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.

Khavinson, V Kh; Linkova, N S; Kvetnoy, I M; Kvetnaia, T V; Polyakova, V O; Korf, H-W

Khavinson, V Kh; Linkova, N S; Kvetnoy, I M; Kvetnaia, T V; Polyakova, V O; Korf, H-W.

Affiliation

Khavinson VKh; I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, Russia.

Bull Exp Biol Med ; 153(2): 255-8, 2012 Jun.

Article in En, Ru | MEDLINE | ID: mdl-22816096

ABSTRACT

ABSTRACT

The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture. Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium. Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.

Subject(s)

Arylalkylamine N-Acetyltransferase/biosynthesis; Cyclic AMP Response Element-Binding Protein/biosynthesis; Dipeptides/pharmacology; Melatonin/biosynthesis; Oligopeptides/pharmacology; Pineal Gland/metabolism; Animals; Cells, Cultured; Male; Norepinephrine/pharmacology; Pineal Gland/cytology; Rats; Rats, Wistar

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Pineal Gland / Cyclic AMP Response Element-Binding Protein / Arylalkylamine N-Acetyltransferase / Dipeptides / Melatonin Limits: Animals Language: En / Ru Journal: Bull Exp Biol Med Year: 2012 Document type: Article Affiliation country: RUSSIA

Search on Google

Add to My VHL

XML

PubMed Links