The molecular mechanism of luteolin-induced apoptosis is potentially             related to inhibition of angiogenesis in human pancreatic carcinoma cells.

Cai, Xueting; Lu, Wuguang; Ye, Tingmei; Lu, Min; Wang, Jianhua; Huo, Jiege; Qian, Shihui; Wang, Xiaoning; Cao, Peng

The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells.

Cai, Xueting; Lu, Wuguang; Ye, Tingmei; Lu, Min; Wang, Jianhua; Huo, Jiege; Qian, Shihui; Wang, Xiaoning; Cao, Peng.

Affiliation

Cai X; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, PR China.

Oncol Rep ; 28(4): 1353-61, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22825765

Subject(s)

Angiogenesis Inhibitors/pharmacology; Luteolin/pharmacology; Neovascularization, Pathologic/drug therapy; Pancreatic Neoplasms/drug therapy; Animals; Apoptosis/drug effects; Cell Cycle Checkpoints/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Chick Embryo; Chorioallantoic Membrane/drug effects; Coculture Techniques; Human Umbilical Vein Endothelial Cells/drug effects; Humans; MAP Kinase Kinase 4/metabolism; NF-kappa B/metabolism; Pancreatic Neoplasms/blood supply; Pancreatic Neoplasms/pathology; Phosphorylation; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Angiogenesis Inhibitors / Luteolin / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Oncol Rep Journal subject: NEOPLASIAS Year: 2012 Document type: Article

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