The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse.

Jacobsen, Jacob P R; Medvedev, Ivan O; Caron, Marc G

Jacobsen, Jacob P R; Medvedev, Ivan O; Caron, Marc G.

Affiliation

Jacobsen JP; Department of Cell Biology, Duke University Medical Center, , Durham, NC 27710, USA. jacob.jacobsen@dm.duke.edu

Philos Trans R Soc Lond B Biol Sci ; 367(1601): 2444-59, 2012 Sep 05.

Article in En | MEDLINE | ID: mdl-22826344

Subject(s)

Depression/physiopathology; Serotonin/deficiency; Tryptophan Hydroxylase/metabolism; Animals; Antidepressive Agents/pharmacology; Arginine/genetics; Arginine/metabolism; Biomarkers/metabolism; Brain/drug effects; Brain/metabolism; Brain/physiopathology; Depression/drug therapy; Depression/genetics; Gene Knock-In Techniques; Histidine/genetics; Histidine/metabolism; Humans; Mice; Polymorphism, Genetic; Selective Serotonin Reuptake Inhibitors/metabolism; Selective Serotonin Reuptake Inhibitors/pharmacology; Suicide/psychology; Synaptic Transmission; Tryptophan Hydroxylase/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan Hydroxylase / Serotonin / Depression Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Philos Trans R Soc Lond B Biol Sci Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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