Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia.

Lee, Chang Seok; Yi, Eun Hee; Lee, Jin-Ku; Won, Cheolhee; Lee, Young Ju; Shin, Min Kyung; Yang, Young Mok; Chung, Myung-Hee; Lee, Jung Weon; Sung, Sang-Hyun; Ye, Sang-Kyu

Lee, Chang Seok; Yi, Eun Hee; Lee, Jin-Ku; Won, Cheolhee; Lee, Young Ju; Shin, Min Kyung; Yang, Young Mok; Chung, Myung-Hee; Lee, Jung Weon; Sung, Sang-Hyun; Ye, Sang-Kyu.

Affiliation

Lee CS; Dept of Pharmacology, Seoul National University College of Medicine, Seoul, Korea.

Eur Respir J ; 41(5): 1147-56, 2013 May.

Article in En | MEDLINE | ID: mdl-22835616

Subject(s)

Chemokine CCL5/metabolism; Neutrophils/drug effects; Pneumonia/chemically induced; Poly I-C/adverse effects; Simvastatin/pharmacology; Animals; Anti-Inflammatory Agents/pharmacology; Bronchi/cytology; Cell Line, Tumor; Disease Models, Animal; Doxycycline/pharmacology; Enzyme-Linked Immunosorbent Assay; Epithelial Cells/cytology; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Inflammation; Lung/drug effects; Mice; Mice, Inbred BALB C; RNA, Small Interfering/metabolism; STAT3 Transcription Factor/metabolism

Key words

Double-stranded RNA; RANTES; inflammation; signal transducer and activator of transcription 3; statin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Poly I-C / Chemokine CCL5 / Simvastatin / Neutrophils Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Eur Respir J Year: 2013 Document type: Article

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