The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties.

Rahman, Khondaker M; Hossain, Mohammad D; Sohrab, Mohammad H; Drake, Alex F; Bui, Tam T; Husby, Jarmila; Gunaratnam, Mekala; Neidle, Stephen; Hasan, Choudhury M; Thurston, David E

Rahman, Khondaker M; Hossain, Mohammad D; Sohrab, Mohammad H; Drake, Alex F; Bui, Tam T; Husby, Jarmila; Gunaratnam, Mekala; Neidle, Stephen; Hasan, Choudhury M; Thurston, David E.

Affiliation

Rahman KM; Department of Pharmacy, King's College London, Stamford Street, London, SE18WA, UK.

Chem Commun (Camb) ; 48(70): 8760-2, 2012 Sep 11.

Article in En | MEDLINE | ID: mdl-22836516

Subject(s)

Acacia/chemistry; Alkaloids/chemistry; Antineoplastic Agents/chemistry; G-Quadruplexes; Telomere/chemistry; Tryptophan/analogs & derivatives; Alkaloids/isolation & purification; Alkaloids/pharmacology; Antineoplastic Agents/isolation & purification; Antineoplastic Agents/pharmacology; Binding Sites; Cell Line, Tumor; Cell Survival/drug effects; DNA/chemistry; Drug Discovery; Fluorescence Resonance Energy Transfer; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Denaturation; Plant Leaves/chemistry; Tryptophan/chemistry; Tryptophan/isolation & purification; Tryptophan/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Telomere / Alkaloids / Acacia / G-Quadruplexes / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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