ALDH2 mediates 5-nitrofuran activity in multiple species.

Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie L; Temperley, Nicholas D; Johnson, Stephen L; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan M; Melton, David W; Smith, Terry K; Tyers, Mike; Westwood, Nicholas J; Patton, E Elizabeth

Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie L; Temperley, Nicholas D; Johnson, Stephen L; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan M; Melton, David W; Smith, Terry K; Tyers, Mike; Westwood, Nicholas J; Patton, E Elizabeth.

Affiliation

Zhou L; School of Chemistry and Biomedical Sciences Research Complex, University of St. Andrews and EaStCHEM, St. Andrews, Fife, Scotland KY16 9ST, UK.

Chem Biol ; 19(7): 883-92, 2012 Jul 27.

Article in En | MEDLINE | ID: mdl-22840776

Subject(s)

Aldehyde Dehydrogenase/metabolism; Melanocytes/drug effects; Nitrofurans/pharmacology; Saccharomyces cerevisiae/drug effects; Aldehyde Dehydrogenase, Mitochondrial; Animals; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Nitrofurans/chemistry; Recombinant Proteins/metabolism; Saccharomyces cerevisiae/metabolism; Species Specificity; Structure-Activity Relationship; Zebrafish/embryology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Aldehyde Dehydrogenase / Melanocytes / Nitrofurans Limits: Animals / Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United States

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