Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component.

Nicholls, Craig; Pinto, Alexander Ruvantha; Li, He; Li, Ling; Wang, Lihui; Simpson, Richard; Liu, Jun-Ping

Nicholls, Craig; Pinto, Alexander Ruvantha; Li, He; Li, Ling; Wang, Lihui; Simpson, Richard; Liu, Jun-Ping.

Affiliation

Nicholls C; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province 310036, China.

Proc Natl Acad Sci U S A ; 109(33): 13308-13, 2012 Aug 14.

Article in En | MEDLINE | ID: mdl-22847419

Subject(s)

Breast Neoplasms/enzymology; Breast Neoplasms/pathology; Cellular Senescence; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/metabolism; RNA/metabolism; Telomerase/metabolism; Breast Neoplasms/genetics; Cell Line, Tumor; Cellular Senescence/drug effects; Female; Gene Expression Regulation, Neoplastic/drug effects; Glyceraldehyde 3-Phosphate/pharmacology; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/chemistry; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/genetics; Green Fluorescent Proteins/metabolism; Humans; NAD/pharmacology; Protein Binding/drug effects; Protein Structure, Tertiary; RNA/antagonists & inhibitors; RNA/chemistry; S-Nitrosoglutathione/pharmacology; Structure-Activity Relationship; Telomerase/antagonists & inhibitors; Telomerase/chemistry; Telomere Shortening/drug effects; Telomere Shortening/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / RNA / Cellular Senescence / Telomerase / Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) Limits: Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2012 Document type: Article Affiliation country: China

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