Paclitaxel-induced endothelial dysfunction in living rats is prevented by nicorandil via reduction of oxidative stress.

Serizawa, Ken-Ichi; Yogo, Kenji; Aizawa, Ken; Tashiro, Yoshihito; Takahari, Yoko; Sekine, Kaori; Suzuki, Toshihiko; Ishizuka, Nobuhiko; Ishida, Hideyuki

Serizawa, Ken-Ichi; Yogo, Kenji; Aizawa, Ken; Tashiro, Yoshihito; Takahari, Yoko; Sekine, Kaori; Suzuki, Toshihiko; Ishizuka, Nobuhiko; Ishida, Hideyuki.

Affiliation

Serizawa K; Product Research Department, Chugai Pharmaceutical Co., Ltd., Japan.

J Pharmacol Sci ; 119(4): 349-58, 2012.

Article in En | MEDLINE | ID: mdl-22850598

Subject(s)

Anti-Arrhythmia Agents/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Arteries/drug effects; Nicorandil/pharmacology; Paclitaxel/pharmacology; Acetylcholine; Animals; Arteries/cytology; Arteries/physiology; Blood Flow Velocity/drug effects; Cells, Cultured; Endothelium, Vascular/drug effects; Endothelium, Vascular/physiopathology; Femoral Artery/drug effects; Femoral Artery/physiology; Humans; Male; Mice; Mice, Inbred ICR; NADPH Oxidases/genetics; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Oxidative Stress/drug effects; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Testis/physiology; Vasodilation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Arteries / Paclitaxel / Nicorandil / Anti-Arrhythmia Agents / Antineoplastic Agents, Phytogenic Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: Japan Country of publication: Japan

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