Elevated expression of AP-1 activity in human breast tumors as compared to normal adjacent tissue.
Anticancer Res
; 10(6): 1711-3, 1990.
Article
in En
| MEDLINE
| ID: mdl-2285246
ABSTRACT
The levels of AP-1 activity in human breast lesions and in adjacent normal tissue were studied by a gel retardation assay. A thirty nucleotide long consensus oligonucleotide to the adenovirus E3 gene AP-1 sequence (E3AP-1) was end labelled and reacted with nuclear extracts from breast lesions and adjacent normal tissue. A total of 20 tissue extracts (8 pairs of tumor and normal tissue from the same patient and 4 tumors) were examined. All 12 tumor tissues showed elevated levels of AP-1 as compared to the 8 normal tissues. These results suggest that the AP-1 transcription factor may play a role in breast neoplasia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Proteins
/
Proto-Oncogene Proteins c-jun
Limits:
Female
/
Humans
Language:
En
Journal:
Anticancer Res
Year:
1990
Document type:
Article
Affiliation country:
Greece