Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia.

Maiorino, C; Khorooshi, R; Ruffini, F; Løbner, M; Bergami, A; Garzetti, L; Martino, G; Owens, T; Furlan, R

Maiorino, C; Khorooshi, R; Ruffini, F; Løbner, M; Bergami, A; Garzetti, L; Martino, G; Owens, T; Furlan, R.

Affiliation

Maiorino C; Clinical Neuroimmunology Unit, Institute of Experimental Neurology-INSpe, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

Gene Ther ; 20(5): 487-96, 2013 May.

Article in En | MEDLINE | ID: mdl-22855093

Subject(s)

Encephalomyelitis, Autoimmune, Experimental/therapy; Entorhinal Cortex; Genetic Therapy; Inflammation/therapy; Interleukin-17/genetics; Animals; Central Nervous System/metabolism; Central Nervous System/pathology; Encephalomyelitis, Autoimmune, Experimental/genetics; Entorhinal Cortex/metabolism; Entorhinal Cortex/pathology; Humans; Inflammation/genetics; Interleukin-17/therapeutic use; Lentivirus/genetics; Macrophages/immunology; Macrophages/metabolism; Mice; Microglia/pathology; Microglia/transplantation; Myeloid Cells/metabolism; Myeloid Cells/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Entorhinal Cortex / Interleukin-17 / Encephalomyelitis, Autoimmune, Experimental / Inflammation Limits: Animals / Humans Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2013 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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